Heading eastward via I-40 over the holidays? Or back westward after them? Resigned to eating at Cracker Barrel or Wendy's along the way?
If you're near the Harriman exit, take it and drive past the chains just a couple of miles for a pretty good Mexican meal.
Two miles or so off the Harriman exit on Highway 27 is El Cantarito 2, a cute Mexican place in an old house. The place is heaving on weekend nights, and maybe it's because nothing else in Harriman is open (but the downtown is very cute).
But the crowd might also be there for the food, because it's good. They make their own chiles rellenos, or did when we were there, and hand-slivered the beef for carne asada. Onions were cooked to the sweet, chewy stage called "tobacco onions," which is slow and labor intensive. Fresh spinach was used in the spinach quesadilla and the sauce for it was a real cream-based sauce.
I don't want to overhype the place -- some of our food was standard-issue splat-Mex. So don't drive two hours just for the food, but if you're in the neighborhood and it's dinner time, El Cantarito is worth knowing about.